European Cyclodextrin Society

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What are cyclodextrins?

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By Thorsteinn Loftsson, University of Iceland.

Cyclodextrins are a group of structurally related natural products formed during bacterial digestion of cellulose. These cyclic oligosaccharides consist of (α-1,4)-linked α-D-glucopyranose units and contain a somewhat lipophilic central cavity and a hydrophilic outer surface. Due to the chair conformation of the glucopyranose units, the cyclodextrins are shaped like a truncated cone rather than perfect cylinders. The hydroxyl functions are orientated to the cone exterior with the primary hydroxyl groups of the sugar residues at the narrow edge of the cone and the secondary hydroxyl groups at the wider edge. The central cavity is lined by the skeletal carbons and ethereal oxygens of the glucose residues, which gives it a lipophilic character. The polarity of the cavity has been estimated to be similar to that of an aqueous ethanolic solution.

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OpenCDLig

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OpenCDLig : A free web application for sharing resources about cyclodextrin/ligand complexes

OpenCDlig

To visit OpenCDLig please go to https://kdd.di.unito.it/casmedchem and please accept the server certificate. For further information's please visit http://www.casmedchem.unito.it/home.html.

 

 

Last Updated on Wednesday, 09 September 2009 10:41
 

The European Cyclodextrin Society

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Welcome to the homepage of the European Cyclodextrin Society. This society is intended to be a platform to strengthen the collaboration among academic scientists and between academia and industry primarily on a European level.

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